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原文：Geographic variation of mutagenic exposures in kidney cancer genomes
链接：https://www.nature.com/articles/s41586-024-07368-2#code-availability
摘要
International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to cancer burden1. In clear cell renal cell carcinoma, obesity, hypertension and tobacco smoking are risk factors, but they do not explain the geographical variation in its incidence2. Underlying causes can be inferred by sequencing the genomes of cancers from populations with different incidence rates and detecting differences in patterns of somatic mutations. Here we sequenced 962 clear cell renal cell carcinomas from 11 countries with varying incidence. The somatic mutation profiles differed between countries. In Romania, Serbia and Thailand, mutational signatures characteristic of aristolochic acid compounds were present in most cases, but these were rare elsewhere. In Japan, a mutational signature of unknown cause was found in more than 70% of cases but in less than 2% elsewhere. A further mutational signature of unknown cause was ubiquitous but exhibited higher mutation loads in countries with higher incidence rates of kidney cancer. Known signatures of tobacco smoking correlated with tobacco consumption, but no signature was associated with obesity or hypertension, suggesting that non-mutagenic mechanisms of action underlie these risk factors. The results of this study indicate the existence of multiple, geographically variable, mutagenic exposures that potentially affect tens of millions of people and illustrate the opportunities for new insights into cancer causation through large-scale global cancer genomics.
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原文图形
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Supplementary Figure
本文对学习R和python的同学非常友好，若你感兴趣可以自行学习。
❝获得本期教程 Data and Code，请在后台回复：20240805。请大家看清楚回复关键词，每天都有很多人回复错误关键词，我这边没时间和精力一一回复。
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往期部分文章
1. 最全WGCNA教程（替换数据即可出全部结果与图形）
2. 精美图形绘制教程
3. 转录组分析教程
4. 转录组下游分析
小杜的生信筆記 ，主要发表或收录生物信息学教程，以及基于R分析和可视化（包括数据分析，图形绘制等）；分享感兴趣的文献和学习资料!!
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